With the fast development of globalization and international profession, the operation environment has become more and more complex than before. As is known, the reason why multiple national companies carry out international business is that they tend to make good use of foreign labor and market advantages to a large extent. The common situation is that multiple national companies also face a series of difficulties not only benefits. From the perspective of foreign labor, these employees with low-cost also have quite different culture backgrounds and this decides that they are not that easy to manage. From the perspective of the international marketing, multiple national companies have to make relative changes about their products and services so as to design local style products because of custom and lifestyle differences. In this essay, it plans to analyze and evaluate the multiple culture issues in modern organization especially for these industries with furious competition. In addition, this essay will make good use of real case from Accenture, which is one famous world top-500, to recommend how to manage these multiple culture issues. As to the structure of this essay, it can be separated into four parts, brief introduction to culture differences, how to manage culture differences, successful experience from Accenture and conclusion.